- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Calbindin 2 antibody detects calbindin 2, also known as calretinin, a calcium-binding protein encoded by the CALB2 gene. Calbindin 2 is expressed in specific neuronal populations and mesothelial cells, where it regulates calcium signaling and contributes to excitability and differentiation. Because calbindin 2 is a widely used marker in neuroscience and mesothelioma pathology, Calbindin 2 antibody is an important reagent in neuroscience, oncology, and calcium biology.
Calbindin 2 belongs to the EF-hand calcium-binding protein family. It modulates intracellular calcium transients, buffering calcium fluxes to regulate signaling cascades, neuronal excitability, and neurotransmission. In pathology, calretinin expression is used diagnostically to identify mesothelioma and to differentiate it from other pleural malignancies. In neuroscience, calbindin 2 marks subsets of interneurons and sensory neurons, providing insights into neuronal circuits and calcium signaling dynamics.
The Calbindin 2 antibody clone CALB2/7029R provides specific and reproducible recognition. Clone CALB2/7029R has been cited in peer-reviewed publications investigating neurodevelopment, calcium signaling, and mesothelioma pathology. Its reproducibility supports immunohistochemistry, immunoblotting, and immunofluorescence applications.
Research using clone CALB2/7029R has demonstrated how calbindin 2 expression serves as a sensitive and specific marker of mesothelial differentiation, aiding in diagnostic pathology. In neuroscience, this antibody has been used to explore the role of calretinin in interneuron excitability and sensory processing. Studies have also highlighted its involvement in developmental regulation of neural circuits and calcium-dependent signaling mechanisms.
NSJ Bioreagents supplies this Calbindin 2 antibody to support neuroscience, oncology, and calcium biology. Alternate designations include CALB2 antibody, calretinin antibody, calcium-binding protein antibody, mesothelial marker antibody, neuronal calcium buffer antibody, and calbindin D29k antibody.
Optimal dilution of the Calbindin 2 antibody should be determined by the researcher.
A portion of amino acids 23-242 was used as the immunogen for the Calbindin 2 antibody.
Aliquot the Calbindin 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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