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Home >> Antibodies >> Cadherin 2 Antibody / CDH2 / N-Cadherin

Cadherin 2 Antibody / CDH2 / N-Cadherin [clone CDH2/9493] (V5635)

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  Catalog No Formulation Size Price (USD)  
Image V5635-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 539
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V5635-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 249
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V5635SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 539
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IHC staining of FFPE human heart tissue with Cadherin 2 antibody (clone CDH2/9493). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human heart tissue with Cadherin 2 antibody (clone CDH2/9493). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Western blot testing of human heart tissue lysate with Cadherin 2 antibody (clone CDH2/9493). Predicted molecular weight ~100 kDa (unmodified), 125-140 kDa (modified).
SDS-PAGE analysis of purified, BSA-free Cadherin 2 antibody (clone CDH2/9493) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b, kappa
Clone Name CDH2/9493
Purity Protein G affinity
UniProt P19022
Localization Cell surface, cytoplasm
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Western Blot : 1-2ug/ml
Limitations This Cadherin 2 antibody is available for research use only.
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Description

Recognizes a protein of ~140kDa, identified as N-Cadherin (NCAD), also known as CD325. NCAD is a member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CD325 is normally involved in inducing cell cycle arrest and its expression is frequently deregulated in cancer cells. Studies have linked N-cadherin to cancer metastasis by showing the aggressive tumor cells had preferentially turned on N-cadherin as opposed to E- or P-cadherin.

Application Notes

Optimal dilution of the Cadherin 2 antibody should be determined by the researcher.

Immunogen

A portion of amino acids 400-600 from human Cadherin 2 protein was used as the immunogen for the Cadherin 2 antibody.

Storage

Aliquot the Cadherin 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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