- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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C1QA antibody detects complement component 1q subcomponent subunit A, encoded by the C1QA gene. C1QA is part of the C1 complex, the recognition unit of the classical complement pathway. Together with subunits C1QB and C1QC, C1QA forms a hexameric bouquet-like structure that binds immune complexes and pathogen-associated ligands, initiating complement activation. Because complement signaling is fundamental to innate immunity, C1QA antibody is important for research in immunology, autoimmunity, and infection biology.
C1QA consists of a collagen-like domain and a globular head region that mediates ligand recognition. Binding of C1q to antibodies or other targets triggers activation of C1r and C1s proteases, initiating the complement cascade. This cascade results in opsonization, inflammation, and lysis of target cells. Beyond host defense, C1QA contributes to clearance of apoptotic cells and immune complexes, preventing autoimmunity.
The C1QA antibody clone C1QA/2956 provides reliable and specific detection. Clone C1QA/2956 has been employed in peer-reviewed studies of complement biology, autoimmune disease, and neuroinflammation. Its performance in immunohistochemistry, immunoblotting, and flow cytometry makes it a versatile tool for studying complement function across model systems.
Research using clone C1QA/2956 has revealed how dysregulation of complement contributes to pathology. In systemic lupus erythematosus, impaired C1q function is linked to defective clearance of apoptotic debris, fueling autoantibody production. In neurodegenerative diseases, C1q has been implicated in synaptic pruning and inflammation, making it a focus of current investigation. Its detection with this antibody allows researchers to map complement activation and study how it shapes both protective and pathological immune responses.
NSJ Bioreagents supplies this C1QA antibody to support immunology, autoimmunity, and complement biology. Alternate names include complement component 1q subcomponent A antibody, C1q alpha chain antibody, complement recognition subunit antibody, classical pathway initiator antibody, and innate immunity complement protein antibody.
Optimal dilution of the C1QA antibody should be determined by the researcher.
A recombinant human partial protein (amino acids 104-237) was used as the immunogen for the C1QA antibody.
Store the C1QA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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