Endothelial Cell Antibody / Antibodies

Endothelial Cell Antibody for Vascular and Inflammatory Research

Endothelial cells form the single-cell layer lining the interior surface of blood and lymphatic vessels. These cells are critical regulators of vascular tone, angiogenesis, immune surveillance, and barrier function. Their roles span both physiological processes—such as tissue perfusion and development—and pathological contexts like tumor progression, atherosclerosis, and chronic inflammation.

To study endothelial cell biology accurately, researchers rely on validated Endothelial Cell Antibody reagents. A high-quality Endothelial Cell Antibody provides specific detection of cell surface and intracellular proteins that are essential to endothelial identity and function.

Key Protein Targets for Endothelial Cell Antibody Detection

Endothelial Cell Antibody tools are commonly developed against the following endothelial-specific or -enriched proteins:

• CD31 (PECAM1): A canonical endothelial marker, widely used to visualize vascular structures and quantify vessel density.

• VE-cadherin (CDH5): A junctional protein critical for maintaining endothelial barrier integrity and cell-cell adhesion.

• E-selectin (SELE): An inducible adhesion molecule involved in leukocyte-endothelial interactions during inflammation.

• Von Willebrand Factor (vWF): A key hemostatic protein that is a hallmark of endothelial lineage, often visualized in Weibel-Palade bodies.

• ICAM1 and VCAM1: Cell adhesion molecules upregulated in activated endothelium during immune responses.

By using a well-characterized Endothelial Cell Antibody, these markers can be readily detected and quantified in both experimental models and human tissue samples.

Endothelial Cell Antibody Applications Across Assays

Researchers deploy Endothelial Cell Antibody products across multiple immunodetection platforms to interrogate vascular dynamics and endothelial signaling.

Immunohistochemistry (IHC)

IHC using an Endothelial Cell Antibody is a cornerstone method to visualize vascular structures in tissue. It helps localize endothelial cells in situ and is commonly used in studies of tumor angiogenesis, vascular remodeling, and inflammation.

Immunofluorescence (IF)

Using fluorescently labeled Endothelial Cell Antibody reagents, researchers can achieve detailed visualization of cell morphology, protein distribution, and junctional architecture at high resolution.

Flow Cytometry

For population analysis and sorting, a Endothelial Cell Antibody provides clear resolution of endothelial cells from mixed cell suspensions. This is particularly useful in isolating endothelial subtypes or tracking activation markers.

Western Blot

Endothelial Cell Antibody products also allow for quantitative protein expression analysis in cell lysates or tissue extracts, helping confirm upregulation or activation in response to stimuli or disease models.

ELISA

In studies measuring soluble endothelial factors like vWF or ICAM1, Endothelial Cell Antibody pairs are employed in sandwich ELISA kits for accurate and sensitive detection in serum or plasma.

Choosing the Right Endothelial Cell Antibody

When selecting an Endothelial Cell Antibody, it’s important to consider the target’s expression profile, tissue specificity, and the assay format. Our collection includes monoclonal and polyclonal antibodies optimized for human and model organisms including mouse, rat, and zebrafish.

Each Endothelial Cell Antibody is rigorously validated for specificity, sensitivity, and compatibility with a variety of detection platforms. Many of our antibodies are also compatible with multiplexing strategies and co-staining with markers for immune cells or endosomal compartments.

Advance Vascular Biology with Confidence

Whether your research focuses on angiogenesis, inflammation, endothelial dysfunction, or vascular remodeling, a high-quality Endothelial Cell Antibody is essential. We invite you to explore our catalog and find the optimal Endothelial Cell Antibody to support your studies in vascular biology and beyond.